Centrobin: A novel daughter centriole-associated protein that is required for centriole duplication

Chaozhong Zou, Jun Li, Yujie Bai, William T. Gunning, David E. Wazer, Vimla Band, Qingshen Gao

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


In mammalian cells, the centrosome consists of a pair of centrioles and amorphous pericentriolar material. The pair of centrioles, which are the core components of the centrosome, duplicate once per cell cycle. Centrosomes play a pivotal role in orchestrating the formation of the bipolar spindle during mitosis. Recent studies have linked centrosomal activity on centrioles or centriole-associated structures to cytokinesis and cell cycle progression through G1 into the S phase. In this study, we have identified centrobin as a centriole-associated protein that asymmetrically localizes to the daughter centriole. The silencing of centrobin expression by small interfering RNA inhibited centriole duplication and resulted in centrosomes with one or no centriole, demonstrating that centrobin is required for centriole duplication. Furthermore, inhibition of centriole duplication by centrobin depletion led to impaired cytokinesis.

Original languageEnglish (US)
Pages (from-to)437-445
Number of pages9
JournalJournal of Cell Biology
Issue number3
StatePublished - Nov 7 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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