Arteropatia cerebral autosomal dominante com infartos subcorticais e leucoencefalopatia (CADASIL) na Argentina

Translated title of the contribution: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina

Maximiliano A. Hawkes, Miguel Wilken, Verónica Bruno, Virginia Pujol-Lereis, Guillermo Povedano, María Saccoliti, Analia Taratuto, Sebastián F. Ameriso

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

CADASIL is the most common cause of hereditary stroke and vascular dementia. Published information about this disease in South America is scant. We describe clinical and demographic characteristics of 13 patients (10 families) with CADASIL from Argentina. Methods: Medical records, diagnostic tests and family history of patients with CADASIL were reviewed. Results: Thirteen patients with CADASIL (10 families) were included. All patients had European ancestry. Initial presentation was stroke in most patients (n = 11). Stroke patients later developed cognitive complaints (n = 9), migraine with aura (n = 1), apathy (n = 4) and depression (n = 6). External capsule and temporal lobe involvement on MRI were characteristic imaging findings. Two patients died after intracerebral hemorrhage. Conclusion: This is the first report of non-related patients with CADASIL in South America addressing ancestry. Since European ancestry is not highly prevalent in all South American countries, there may be variable incidence of CADASIL within this region.

Translated title of the contributionCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina
Original languagePortuguese
Pages (from-to)751-754
Number of pages4
JournalArquivos de Neuro-Psiquiatria
Volume73
Issue number9
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Keywords

  • CADASIL
  • Leukoencephalopathy
  • South America
  • Stroke
  • Vascular dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry

Fingerprint

Dive into the research topics of 'Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina'. Together they form a unique fingerprint.

Cite this