TY - JOUR
T1 - Cerebral circulation during diabetes mellitus
AU - Mayhan, William G.
N1 - Funding Information:
Acknowledgements--Ori~nal studies were supported by funds from the National Heart, Lung and Blood Institute Grant HL-40781, a Research Career Development Award HL-02124, a Grant-in-Aid from the American Heart Association (National Affiliate; 91006230), a Grant-in-Aid from the American Heart Association (Nebraska Affiliate; NE-89-G-21), a Grant-in-Aid from the American Heart Association (Iowa Affiliate; IA-87-G-22) and from the Nebraska Cancer and Smoking Disease Research Program (92-32).
PY - 1993
Y1 - 1993
N2 - Diabetes mellitus is characterized by hyperglycemia, a decrease in circulating insulin and the development of macro- and microvascular pathology. Hyperglycemia appears to be a primary determinant for the structural, biochemical and functional changes that occur in large and small blood vessels during diabetes mellitus. While much research has focused on the effects of diabetes mellitus on the peripheral circulation, it is clear that diabetes mellitus also has profound effects on the cerebral circulation. Thus, the focus of this review is to discuss morphological and functional alterations in the cerebral circulation during diabetes mellitus.
AB - Diabetes mellitus is characterized by hyperglycemia, a decrease in circulating insulin and the development of macro- and microvascular pathology. Hyperglycemia appears to be a primary determinant for the structural, biochemical and functional changes that occur in large and small blood vessels during diabetes mellitus. While much research has focused on the effects of diabetes mellitus on the peripheral circulation, it is clear that diabetes mellitus also has profound effects on the cerebral circulation. Thus, the focus of this review is to discuss morphological and functional alterations in the cerebral circulation during diabetes mellitus.
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U2 - 10.1016/0163-7258(93)90062-I
DO - 10.1016/0163-7258(93)90062-I
M3 - Article
C2 - 8361999
AN - SCOPUS:0027167904
SN - 0163-7258
VL - 57
SP - 377
EP - 391
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 2-3
ER -