Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.
|Original language||English (US)|
|Number of pages||3|
|Journal||Bone marrow transplantation|
|State||Published - Jan 1 1991|
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