Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation

B. G. Gordon; K. L. Saving; J. A. McCallister; P. I. Warkentin; J. R.W.M. McConnell Roberts; P. F. Coccia; W. D. Haire

Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation

B. G. Gordon, K. L. Saving, J. A. McCallister, P. I. Warkentin, J. R.W.M. McConnell Roberts, P. F. Coccia, W. D. Haire

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Abstract

Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.

Original language	English (US)
Pages (from-to)	323-325
Number of pages	3
Journal	Bone marrow transplantation
Volume	8
Issue number	4
State	Published - 1991

ASJC Scopus subject areas

Hematology
Transplantation

Cite this

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title = "Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation",

abstract = "Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.",

author = "Gordon, {B. G.} and Saving, {K. L.} and McCallister, {J. A.} and Warkentin, {P. I.} and {McConnell Roberts}, {J. R.W.M.} and Coccia, {P. F.} and Haire, {W. D.}",

year = "1991",

language = "English (US)",

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T1 - Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation

AU - Gordon, B. G.

AU - Saving, K. L.

AU - McCallister, J. A.

AU - Warkentin, P. I.

AU - McConnell Roberts, J. R.W.M.

AU - Coccia, P. F.

AU - Haire, W. D.

PY - 1991

Y1 - 1991

N2 - Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.

AB - Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.

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M3 - Article

C2 - 1756332

AN - SCOPUS:0026007050

SN - 0268-3369

VL - 8

SP - 323

EP - 325

JO - Bone marrow transplantation

JF - Bone marrow transplantation

IS - 4

ER -

Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation

Abstract

ASJC Scopus subject areas

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