Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation

B. G. Gordon, K. L. Saving, J. A. McCallister, P. I. Warkentin, J. R.W.M. McConnell Roberts, P. F. Coccia, W. D. Haire

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.

Original languageEnglish (US)
Pages (from-to)323-325
Number of pages3
JournalBone marrow transplantation
Volume8
Issue number4
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Gordon, B. G., Saving, K. L., McCallister, J. A., Warkentin, P. I., McConnell Roberts, J. R. W. M., Coccia, P. F., & Haire, W. D. (1991). Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation. Bone marrow transplantation, 8(4), 323-325.