Cerulenin inhibition of spore germination in Rhizopus stolonifer

Kenneth W. Nickerson, Elaine Leastman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We have used cerulenin, a known inhibitor of fatty acid synthesis, to study essential fatty acid and membrane syntheses during spore germination. Cerulenin (4 μg/ml) prevented the germination of Rhizopus stolonifer sporangiospores and this inhibition was reversed by Tween 80. Specifically, spore swelling, germ tube formation, and, probably, mitochondrial biogenesis were inhibited, whereas, during the first 2 h at least, the rates of protein and RNA syntheses and oxygen uptake remained undiminished. We conclude that de novo fatty acid synthesis is necessary for spore germination.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalExperimental Mycology
Issue number1
StatePublished - Mar 1978


  • Rhizopus stolonifer
  • cerulenin
  • glyoxalate cycle
  • membrane synthesis
  • mitochondrial biogenesis
  • spore germination

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology


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