Challenges and lessons learned in conducting comparative-effectiveness trials

Linda M. Herrick, G. Richard Locke, Alan R. Zinsmeister, Nicholas J. Talley

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

The current health-care environment is demanding evidence-based medicine that relies on clinical trials as the basis for decisions. Clinician investigators are more often finding that they are personally responsible for coordinating large, multisite trials. We present strategies for successful implementation and management of multisite clinical trials and knowledge gained through an international, multisite randomized clinical trial. Topics include team composition, regulatory requirements, study organization and governance, communication strategies, recruitment and retention efforts, budget, technology transfer, and publication.

Original languageEnglish (US)
Pages (from-to)644-649
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume107
Issue number5
DOIs
StatePublished - May 2012

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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