Challenges in clinical trial design in inflammatory arthritis

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The prognosis for patients with rheumatoid arthritis has improved dramatically, thanks in large part to many new therapies and therapeutic approaches. Paradoxically, this has created problems for rheumatologists since clinically useful information from appropriate clinical trials has not kept pace with all the new therapeutic options. Essentially, rheumatologists now have many more therapeutic options than they know what to do with. This article discusses why we are in this situation and suggests opportunities to move forward.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalBest Practice and Research: Clinical Rheumatology
Issue number4
StatePublished - Aug 2010


  • clinical trials
  • comparative effectiveness research
  • ethics
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology


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