Changes in endogenous DNA damage in aging mice in response to butylated hydroxyanisole and oltipraz

Terence Lawson; Sidney Stohs

doi:10.1016/0047-6374(85)90006-5

Changes in endogenous DNA damage in aging mice in response to butylated hydroxyanisole and oltipraz

Terence Lawson, Sidney Stohs

Eppley Institute for Cancer Research

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The extent of DNA damage (single strand breaks) was measured in the livers of female Swiss-Webster mice up to 24 months of age. The effects of the antioxidants butylated hydroxyanisole (BHA) and oltipraz on this DNA damage were also measured. Oltipraz is an antioxidant which is structurally related to compounds found in cruciferous vegetables. From 6 months on the extent of DNA damage increased, reaching a maximum about 18 months old. Limited administration of both BHA and oltipraz to mice significantly reduced the levels of hepatic DNA damage.

Original language	English (US)
Pages (from-to)	179-185
Number of pages	7
Journal	Mechanisms of Ageing and Development
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/0047-6374(85)90006-5
State	Published - May 13 1985

Keywords

Aging
Antioxidant
DNA damage
Glutathione

ASJC Scopus subject areas

Aging
Developmental Biology

Access to Document

10.1016/0047-6374(85)90006-5

Cite this

@article{2cf27ceb0d3d435c8c4ef8c8b6376cc3,

title = "Changes in endogenous DNA damage in aging mice in response to butylated hydroxyanisole and oltipraz",

abstract = "The extent of DNA damage (single strand breaks) was measured in the livers of female Swiss-Webster mice up to 24 months of age. The effects of the antioxidants butylated hydroxyanisole (BHA) and oltipraz on this DNA damage were also measured. Oltipraz is an antioxidant which is structurally related to compounds found in cruciferous vegetables. From 6 months on the extent of DNA damage increased, reaching a maximum about 18 months old. Limited administration of both BHA and oltipraz to mice significantly reduced the levels of hepatic DNA damage.",

keywords = "Aging, Antioxidant, DNA damage, Glutathione",

author = "Terence Lawson and Sidney Stohs",

note = "Funding Information: *Funded by a grant from the State of Nebraska Department of Health.",

year = "1985",

month = may,

day = "13",

doi = "10.1016/0047-6374(85)90006-5",

language = "English (US)",

volume = "30",

pages = "179--185",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Changes in endogenous DNA damage in aging mice in response to butylated hydroxyanisole and oltipraz

AU - Lawson, Terence

AU - Stohs, Sidney

N1 - Funding Information: *Funded by a grant from the State of Nebraska Department of Health.

PY - 1985/5/13

Y1 - 1985/5/13

N2 - The extent of DNA damage (single strand breaks) was measured in the livers of female Swiss-Webster mice up to 24 months of age. The effects of the antioxidants butylated hydroxyanisole (BHA) and oltipraz on this DNA damage were also measured. Oltipraz is an antioxidant which is structurally related to compounds found in cruciferous vegetables. From 6 months on the extent of DNA damage increased, reaching a maximum about 18 months old. Limited administration of both BHA and oltipraz to mice significantly reduced the levels of hepatic DNA damage.

AB - The extent of DNA damage (single strand breaks) was measured in the livers of female Swiss-Webster mice up to 24 months of age. The effects of the antioxidants butylated hydroxyanisole (BHA) and oltipraz on this DNA damage were also measured. Oltipraz is an antioxidant which is structurally related to compounds found in cruciferous vegetables. From 6 months on the extent of DNA damage increased, reaching a maximum about 18 months old. Limited administration of both BHA and oltipraz to mice significantly reduced the levels of hepatic DNA damage.

KW - Aging

KW - Antioxidant

KW - DNA damage

KW - Glutathione

UR - http://www.scopus.com/inward/record.url?scp=0021799449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021799449&partnerID=8YFLogxK

U2 - 10.1016/0047-6374(85)90006-5

DO - 10.1016/0047-6374(85)90006-5

M3 - Article

C2 - 4021555

AN - SCOPUS:0021799449

SN - 0047-6374

VL - 30

SP - 179

EP - 185

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 2

ER -

Changes in endogenous DNA damage in aging mice in response to butylated hydroxyanisole and oltipraz

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this