TY - JOUR
T1 - Changes in glutathione and glutathione metabolizing enzymes in erythrocytes and lymphocytes of mice as a function of age
AU - Stohs, S. J.
AU - Lawson, T.
AU - Al-Turk, W. A.
N1 - Funding Information:
Acknowledgements--Tshtuisd yw ass upporteIdn partb y a grant from the NebraskaS tateH ealthD epartmen(tL B 506) The authortsh ankJa neD eVasurea ndM rs Mary Beth Reynoldsfo r technicaal ssistance
PY - 1984
Y1 - 1984
N2 - 1. 1. Changes in reduced glutathione levels in liver, lung and whole blood of female Swiss-Webster mice with age were determined. In addition, glutathione content, and glutathione S-transferase and glutathione reductase activities of erythrocytes and lymphocytes of mice as a function of age were examined. 2. 2. Reduced glutathione content increased in liver, lung, whole blood, erythrocytes and lymphocytes with age from 3 to 9 months, reached a maximum level at 9 months of age and decreased thereafter with advanced age in all tissues. 3. 3. Glutathione S-transferase and glutathione reductase activities in erythrocytes and lymphocytes increased with age from 3 to 9 months, reached maximum activities at 9 months and decreased thereafter with advanced age. 4. 4. The glutathione content of erythrocytes from animals 18 months of age decreased by 56% as compared to 9 month old mice, while the activities of glutathione S-transferase and glutathione reductase decreased by 56 and 48%, respectively, over the same age span.
AB - 1. 1. Changes in reduced glutathione levels in liver, lung and whole blood of female Swiss-Webster mice with age were determined. In addition, glutathione content, and glutathione S-transferase and glutathione reductase activities of erythrocytes and lymphocytes of mice as a function of age were examined. 2. 2. Reduced glutathione content increased in liver, lung, whole blood, erythrocytes and lymphocytes with age from 3 to 9 months, reached a maximum level at 9 months of age and decreased thereafter with advanced age in all tissues. 3. 3. Glutathione S-transferase and glutathione reductase activities in erythrocytes and lymphocytes increased with age from 3 to 9 months, reached maximum activities at 9 months and decreased thereafter with advanced age. 4. 4. The glutathione content of erythrocytes from animals 18 months of age decreased by 56% as compared to 9 month old mice, while the activities of glutathione S-transferase and glutathione reductase decreased by 56 and 48%, respectively, over the same age span.
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U2 - 10.1016/0306-3623(84)90173-3
DO - 10.1016/0306-3623(84)90173-3
M3 - Article
C2 - 6735142
AN - SCOPUS:0021272076
SN - 0306-3623
VL - 15
SP - 267
EP - 270
JO - General Pharmacology
JF - General Pharmacology
IS - 3
ER -