@article{0098bcc1e9724b83a8435486e559fc0c,
title = "Changes in lipid classes of Drosophila melanogaster in response to selection for three stress traits",
abstract = "Laboratory selection on environmental stress traits is an evolutionary approach that is informative in the context of understanding stress adaptation. Here we characterize changes in a lipidome of Drosophila melanogaster in lines selected for increased heat (elevated heat knockdown refractoriness), cold (decreased time to recover from chill-coma) and desiccation survival. Selection for desiccation resistance resulted in changes in multiple lipid classes used to characterize a lipidome. This included a decrease in triacylglycerols (TAGs) which is relevant to interpretation of storage lipid levels in previous D. melanogaster desiccation survival selection experiments. Chill-coma recovery rate selection was expected to show extensive changes in lipid classes, but only phosphatidic acids exhibited significant change. Selection for increased heat knockdown resistance resulted in a substantial change in the abundance of a class of lipids (diacylglycerols) which could play a role in mediating the heat shock response or result in an increase in neutral lipid mobilization.",
keywords = "Chill-coma, Desiccation, Drosophila melanogaster, Heat, Laboratory selection, Lipid metabolome, Lipid profile, Stress resistance, Stress selection",
author = "Li Ko and Lawrence Harshman and Sandra Hangartner and Ary Hoffmann and S. Kachman and Paul Black",
note = "Funding Information: We thank Anthony Zera (Biological Sciences) for intellectual stimulation in the context of the study of lipids, and for service on Li Ko{\textquoteright}s dissertation committee. Appreciation is conveyed to Thomas Helikar (Biochemistry) who provided valuable perspectives on lipids as a member of Li Ko{\textquoteright}s dissertation committee. A.A. Hoffmann was supported by a grant from the Science Industry Endowment fund and a Laureate Fellowship from the Australian Research Council , Australia. L.G. Harshman was supported by an Army Research Office grant ( AR45071-LS-DPS ), United States. Funding Information: We thank Anthony Zera (Biological Sciences) for intellectual stimulation in the context of the study of lipids, and for service on Li Ko's dissertation committee. Appreciation is conveyed to Thomas Helikar (Biochemistry) who provided valuable perspectives on lipids as a member of Li Ko's dissertation committee. A.A. Hoffmann was supported by a grant from the Science Industry Endowment fund and a Laureate Fellowship from the Australian Research Council, Australia. L.G. Harshman was supported by an Army Research Office grant (AR45071-LS-DPS), United States.",
year = "2019",
month = aug,
day = "1",
doi = "10.1016/j.jinsphys.2019.103890",
language = "English (US)",
volume = "117",
journal = "Journal of Insect Physiology",
issn = "0022-1910",
publisher = "Elsevier Limited",
}