Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

Michael A. Hollingsworth; Donald L. Evans

doi:10.1016/0047-6374(83)90086-6

Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

Michael A. Hollingsworth, Donald L. Evans

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.

Original language	English (US)
Pages (from-to)	321-333
Number of pages	13
Journal	Mechanisms of Ageing and Development
Volume	22
Issue number	3-4
DOIs	https://doi.org/10.1016/0047-6374(83)90086-6
State	Published - 1983
Externally published	Yes

Keywords

Aging
Cell mediated immunity
Proliferation responses
Suppressor cells
Tumor immunity

ASJC Scopus subject areas

Aging
Developmental Biology

Access to Document

10.1016/0047-6374(83)90086-6

Fingerprint Dive into the research topics of 'Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats'. Together they form a unique fingerprint.

Cite this

@article{5e01f764551342a4a201c2373e3fe8eb,

title = "Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats",

abstract = "New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.",

keywords = "Aging, Cell mediated immunity, Proliferation responses, Suppressor cells, Tumor immunity",

author = "Hollingsworth, {Michael A.} and Evans, {Donald L.}",

year = "1983",

doi = "10.1016/0047-6374(83)90086-6",

language = "English (US)",

volume = "22",

pages = "321--333",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

number = "3-4",

}

TY - JOUR

T1 - Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

AU - Hollingsworth, Michael A.

AU - Evans, Donald L.

PY - 1983

Y1 - 1983

N2 - New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.

AB - New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.

KW - Aging

KW - Cell mediated immunity

KW - Proliferation responses

KW - Suppressor cells

KW - Tumor immunity

UR - http://www.scopus.com/inward/record.url?scp=0020791873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020791873&partnerID=8YFLogxK

U2 - 10.1016/0047-6374(83)90086-6

DO - 10.1016/0047-6374(83)90086-6

M3 - Article

C2 - 6226837

AN - SCOPUS:0020791873

VL - 22

SP - 321

EP - 333

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 3-4

ER -