Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

Michael A. Hollingsworth; Donald L. Evans

doi:10.1016/0047-6374(83)90086-6

Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

Michael A. Hollingsworth, Donald L. Evans

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.

Original language	English (US)
Pages (from-to)	321-333
Number of pages	13
Journal	Mechanisms of Ageing and Development
Volume	22
Issue number	3-4
DOIs	https://doi.org/10.1016/0047-6374(83)90086-6
State	Published - 1983
Externally published	Yes

Keywords

Aging
Cell mediated immunity
Proliferation responses
Suppressor cells
Tumor immunity

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/0047-6374(83)90086-6

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title = "Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats",

abstract = "New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.",

keywords = "Aging, Cell mediated immunity, Proliferation responses, Suppressor cells, Tumor immunity",

author = "Hollingsworth, {Michael A.} and Evans, {Donald L.}",

note = "Funding Information: This work has been supported in part by grants from the National Cancer Institute PHS grant number 5T32, CA09422, the Gaston County Cancer Society, the Edward and Ruth Diehl Foundation, and the American Cancer Society IM 220. The authors gratefully acknowledge the technical asststance of Karen Hol-lingsworth and Jay E. Hememann and the clerical assistance of Phyllis Hamilton and Bonnie Askea.",

year = "1983",

doi = "10.1016/0047-6374(83)90086-6",

language = "English (US)",

volume = "22",

pages = "321--333",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

number = "3-4",

}

TY - JOUR

T1 - Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

AU - Hollingsworth, Michael A.

AU - Evans, Donald L.

N1 - Funding Information: This work has been supported in part by grants from the National Cancer Institute PHS grant number 5T32, CA09422, the Gaston County Cancer Society, the Edward and Ruth Diehl Foundation, and the American Cancer Society IM 220. The authors gratefully acknowledge the technical asststance of Karen Hol-lingsworth and Jay E. Hememann and the clerical assistance of Phyllis Hamilton and Bonnie Askea.

PY - 1983

Y1 - 1983

N2 - New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.

AB - New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.

KW - Aging

KW - Cell mediated immunity

KW - Proliferation responses

KW - Suppressor cells

KW - Tumor immunity

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DO - 10.1016/0047-6374(83)90086-6

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C2 - 6226837

AN - SCOPUS:0020791873

VL - 22

SP - 321

EP - 333

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 3-4

ER -

Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

Abstract

Keywords

ASJC Scopus subject areas

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