Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

Michael A. Hollingsworth, Donald L. Evans

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.

Original languageEnglish (US)
Pages (from-to)321-333
Number of pages13
JournalMechanisms of Ageing and Development
Volume22
Issue number3-4
DOIs
StatePublished - 1983

Keywords

  • Aging
  • Cell mediated immunity
  • Proliferation responses
  • Suppressor cells
  • Tumor immunity

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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