Abstract
New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.
Original language | English (US) |
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Pages (from-to) | 321-333 |
Number of pages | 13 |
Journal | Mechanisms of Ageing and Development |
Volume | 22 |
Issue number | 3-4 |
DOIs | |
State | Published - 1983 |
Externally published | Yes |
Keywords
- Aging
- Cell mediated immunity
- Proliferation responses
- Suppressor cells
- Tumor immunity
ASJC Scopus subject areas
- Aging
- Developmental Biology