Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

Michael A. Hollingsworth; Donald L. Evans

doi:10.1016/0047-6374(83)90086-6

Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats

Michael A. Hollingsworth, Donald L. Evans

Research output: Contribution to journal › Article

4 Scopus citations

Abstract

New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.

Original language	English (US)
Pages (from-to)	321-333
Number of pages	13
Journal	Mechanisms of Ageing and Development
Volume	22
Issue number	3-4
DOIs	https://doi.org/10.1016/0047-6374(83)90086-6
State	Published - 1983

Keywords

Aging
Cell mediated immunity
Proliferation responses
Suppressor cells
Tumor immunity

ASJC Scopus subject areas

Aging
Developmental Biology

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Hollingsworth, M. A., & Evans, D. L. (1983). Changes in spleen cell proliferative responses and resistance to syngeneic tumor challenge in aging NBR rats. Mechanisms of Ageing and Development, 22(3-4), 321-333. https://doi.org/10.1016/0047-6374(83)90086-6

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abstract = "New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.",

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