Changes in the Surface of the Mouse Blastocyst at Implantation

Michael I. Sherman, Ruth Shalgi, Angie Rizzino, Martin H. Sellens, Steffen Gay, Renate Gay

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Implantation is a critical event, and perhaps the earliest one, in the maternal recognition of pregnancy. Information transfer from conceptus to mother might occur during, and subsequent to, implantation at the level of cell surface interaction. Therefore, attempts have been made both to identify the phases of implantation during which changes in the blastocyst surface occur and to characterize such changes. In vitro, blastocysts have been found to go through a series of discrete steps which are analogous to implantation in utero, and these steps can be retarded or prevented by the use of either suboptimal culture media or an inappropriate substratum. Morphological surface changes are not apparent when the blastocyst becomes adherent to the substratum; however, marked differences in blastocyst surface structure are revealed by scanning electron microscopy at the onset of trophoblast outgrowth. Studies at the molecular level implicate collagen as having a role in blastocyst adhesiveness, but other cell surface components are also likely to be involved.

Original languageEnglish (US)
Title of host publicationMaternal Recognition of Pregnancy
Number of pages20
ISBN (Electronic)9780470720479
ISBN (Print)0444900616, 9780444900616
StatePublished - May 30 2008
Externally publishedYes


  • Cell surface interaction
  • Implantation
  • Mammalian embryo
  • Mouse blastocyst
  • Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

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