Objective: To explore the relation of β-adrenoreceptor density and function to patient's condition in patients with essential hypertension (EH). Methods: Sixty-nine male patients with EH at different stages were included in study and 30 healthy subjects were used as control. β-adrenoreceptor maximum bound volume (β(max)) in peripheral lymphocytes was measured by 3H- dihydroalprenolol (3H-DHA) radio ligand binding. β-adrenoreceptor responsiveness was determined by Salbutamol (injection). Results: β(max) was significantly higher in patients with EH at stages I and II (P < 0.01 and P < 0.001, respectively) and the chronotropic dose of Salbutamol required to increase hear rate by 30 beats/min (CD30) was significantly lower (P <0.01 and P < 0.001, respectively) than that in control group. β(max) was significantly lower and CD30 was significantly higher (all P < 0.01) in patients with EH at stage III than those in control group. β(max) was significantly higher and CD30 was significantly lower (all P < 0.001) in patients with EH with left ventricular hypertrophy (LVH) than in those without LVH. β(max) was significantly lower and CD30 was significantly higher (all P < 0.001) in patients with EH and heart failure than in those without heart failure. Conclusion: β-adrenoreceptor plays a role in the pathogenesis of hypertension, hypertension complicated with ventricular hypertrophy and heart failure. β-adrenoreceptor density and function may be viewed as an index for evaluating hypertensive patient's condition.
|Original language||English (US)|
|Number of pages||3|
|Journal||Chinese Journal of Cardiology|
|State||Published - Jan 1 1999|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine