Chapter 7 Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex

David A. Lewis, Karoly Mirnics

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

The availability of methods for quantifying tissue concentrations of messenger RNAs in the postmortem of the human brain has provided a number of new findings in schizophrenia. However, understanding how these findings actually relate to the disease process of schizophrenia requires knowledge both of the factors that might give rise to such changes in gene expression and of the impact of these changes on the function of the affected neural circuits. Consequently, this chapter provides a review of the potential causes and consequences of some of the schizophrenia-related transcriptome changes in the dorsolateral prefrontal cortex, a brain region implicated in the pathophysiology of certain core cognitive deficits in this illness.

Original languageEnglish (US)
Title of host publicationFunctional Genomics and Proteomics in the Clinical Neurosciences
EditorsS.E. Hemby, S. Bahn
Pages141-152
Number of pages12
DOIs
StatePublished - 2006

Publication series

NameProgress in Brain Research
Volume158
ISSN (Print)0079-6123

Keywords

  • GABA
  • glutamic acid decarboxylase
  • prefrontal cortex
  • regulator of G-protein signaling 4
  • schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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    Lewis, D. A., & Mirnics, K. (2006). Chapter 7 Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex. In S. E. Hemby, & S. Bahn (Eds.), Functional Genomics and Proteomics in the Clinical Neurosciences (pp. 141-152). (Progress in Brain Research; Vol. 158). https://doi.org/10.1016/S0079-6123(06)58007-0