TY - JOUR
T1 - Characteristic physical traits of first-grade children in the United States with fetal alcohol spectrum disorders (FASD) and associated alcohol and drug exposures
AU - May, Philip A.
AU - Hasken, Julie M.
AU - Manning, Melanie A.
AU - Robinson, Luther K.
AU - Abdul-Rahman, Omar
AU - Adam, Margaret P.
AU - Jewett, Tamison
AU - Elliott, Amy
AU - Kalberg, Wendy O.
AU - Buckley, David
AU - Hoyme, H. Eugene
N1 - Funding Information:
This project was funded by the National Institutes of Health (NIH), the National Institute on Alcohol Abuse, and Alcoholism (NIAAA), grant UO1 AA019894. The authors have no financial relationship relevant to this article to disclose. The authors have no conflict of interest to declare. Marcia Scott, Ph.D., Kenneth Warren, Ph.D., Faye Calhoun, D.P.A., Enoch Gordis, M.D., and the late T‐K Li, M.D. of NIAAA provided intellectual guidance, encouragement, and support for diagnostic, epidemiologic, and prevention studies of FASD for over three decades. We are also grateful for the advice and participation in the planning and implementation of the CoFASP collaboration by the Advisory Committee members who were led by Marcia Scott, Ph.D., NIAAA Project Officer, Judith Arroyo, Ph.D., Michael Charness, M.D., William Dunty, Ph.D., Daniel Falk, Ph.D., Dale Herald, M.D., Ph.D., and Edward Riley, Ph.D.
Funding Information:
This project was funded by the National Institutes of Health (NIH), the National Institute on Alcohol Abuse, and Alcoholism (NIAAA), grant UO1 AA019894 as part of the Collaboration on Fetal Alcohol Spectrum Disorders Prevalence (CoFASP) consortium.
Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2022/7
Y1 - 2022/7
N2 - We compared growth, physical features, and minor anomalies in 131 first-grade children with fetal alcohol spectrum disorders (FASD) to those of a representative comparison group of typically developing children from the same populations (n = 1212). The data were collected from three regional sites in the NIAAA-funded Collaboration on FASD Prevalence (CoFASP). Dysmorphology examinations were performed by a team of expert clinical geneticists, and FASD diagnoses were assigned according to the Revised Institute of Medicine Guidelines, which include assessments of growth, dysmorphology, neurobehavior, and maternal risk interviews. We present detailed data on 32 physical traits, minor anomalies, and a summary dysmorphology score for children within each of the four diagnostic categories in the continuum of FASD. There were few differences in the frequency of FASD diagnoses by race or Hispanic ethnicity. Children with FASD were born to mothers who reported using alcohol, tobacco (28.3%), and other drugs (14.2%) during pregnancy. Controlling for tobacco and other drug use, risk analysis indicated that women with a drinking pattern of 3 drinks per drinking day prior to pregnancy were 10 times more likely (p < 0.001, OR = 9.92, 95% CI: 4.6–21.5) to bear a child with FASD than those who reported abstinence prior to pregnancy.
AB - We compared growth, physical features, and minor anomalies in 131 first-grade children with fetal alcohol spectrum disorders (FASD) to those of a representative comparison group of typically developing children from the same populations (n = 1212). The data were collected from three regional sites in the NIAAA-funded Collaboration on FASD Prevalence (CoFASP). Dysmorphology examinations were performed by a team of expert clinical geneticists, and FASD diagnoses were assigned according to the Revised Institute of Medicine Guidelines, which include assessments of growth, dysmorphology, neurobehavior, and maternal risk interviews. We present detailed data on 32 physical traits, minor anomalies, and a summary dysmorphology score for children within each of the four diagnostic categories in the continuum of FASD. There were few differences in the frequency of FASD diagnoses by race or Hispanic ethnicity. Children with FASD were born to mothers who reported using alcohol, tobacco (28.3%), and other drugs (14.2%) during pregnancy. Controlling for tobacco and other drug use, risk analysis indicated that women with a drinking pattern of 3 drinks per drinking day prior to pregnancy were 10 times more likely (p < 0.001, OR = 9.92, 95% CI: 4.6–21.5) to bear a child with FASD than those who reported abstinence prior to pregnancy.
KW - FASD physical phenotypes
KW - alcohol use in pregnancy
KW - fetal alcohol spectrum disorders (FASD)
KW - maternal risk for FASD
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U2 - 10.1002/ajmg.a.62738
DO - 10.1002/ajmg.a.62738
M3 - Article
C2 - 35357075
AN - SCOPUS:85127451687
SN - 1552-4825
VL - 188
SP - 2019
EP - 2035
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 7
ER -