Characteristics of pathologic complete response for locally advanced rectal cancer

Adam J. Cloos, Makayla Schissel, Rishi Batra, Steven R. Donahue, Chelsea D. Wenos, Terrence Kumar, Jennifer A. Leinicke, Jon S Thompson, Sean J. Langenfeld

Research output: Contribution to journalArticlepeer-review


Background: Neoadjuvant chemoradiation (NACRT) is the standard of care for locally advanced rectal cancers. The purpose of this study was to determine patient and tumor factors associated with a pathologic complete response (pCR). Methods: The National Surgical Quality Improvement Program proctectomy-targeted database was utilized to identify all patients from 2016 to 2020 who underwent NACRT followed by proctectomy with curative intent for T3-4N0-2 rectal cancers. Results: A total of 1891 patients were included, of which 253 (13.4%) demonstrated a pCR. Pretreatment N0 staging was associated with a higher rate of pCR (18.9%) when compared to N1 (6.7%) and N2 (6.7%) (p < 0.0001). Patients clinically staged at T3N0 had the highest rate of pCR (19.5%). Gender, age, race, weight, smoking status, and tumor height were not associated with pCR. Conclusions: Patients with cN0 disease were more likely to experience a pCR compared to cN1-2 patients. Tumor height relative to anal verge or patient demographics were not associated with pCR.

Original languageEnglish (US)
JournalAmerican journal of surgery
StateAccepted/In press - 2023


  • Associative factors
  • Pathologic complete response
  • Rectal cancer

ASJC Scopus subject areas

  • Surgery


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