Characterization of Antibodies to a Placenta‐Specific Antigen Cross‐Reacting With a Choriocarcinoma Cell Line

Subrata Sinha, Alok Bhattacharya, Abdul Hamid Band, Amitabh Gaur, L. M. Strivastava, G. P. Talwar

Research output: Contribution to journalArticle

Abstract

ABSTRACT: Antibodies were raised in rabbits to purified human term placental villous plasma membrane. These were cytotoxic to human peripheral blood lymphocytes and manifested cross‐reactivity to kidney and liver. After absorption with these tissues, reactivity was retained with placental villous plasma membrane. The placental‐specific antiserum was fully reactive with BeWo choriocarcinoma cells, but was devoid of reaction with a human myeloma tumor cell line (GM2132). The antibodies were cytotoxic to BeWo in the presence of complement, as determined by trypan blue uptake, 51Cr release, and inhibition of uptake of 3H‐thymidine. 1984 Munksgaard

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalAmerican Journal of Reproductive Immunology
Volume6
Issue number3
DOIs
StatePublished - 1984

Keywords

  • Oncofetal antigens
  • choriocarcinoma
  • cytotoxic antibodies
  • placental plasma membrane

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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