Characterization of lipid-templated silica and hybrid thin film mesophases by grazing incidence small-angle X-ray scattering

Darren R. Dunphy, Todd M. Alam, Michael P. Tate, Hugh W. Hillhouse, Bernd Smarsly, Andrew D. Collord, Eric Carnes, Helen K. Baca, Ralf Köhn, Michael Sprung, Jin Wang, C. Jeffrey Brinker

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The nanostructure of silica and hybrid thin film mesophases templated by phospholipids via an evaporation-induced self-assembly (EISA) process was investigated by grazing-incidence small-angle X-ray scattering (GISAXS). Diacyl phosphatidylcholines with two tails of 6 or 8 carbons were found to template 2D hexagonal mesophases, with the removal of lipid from these lipid/silica films by thermal or UV/O3 processing resulting in a complete collapse of the pore volume. Monoacyl phosphatidylcholines with single tails of 10-14 carbons formed 3D micellular mesophases; the lipid was found to be extractable from these 3D materials, yielding a porous material. In contrast to pure lipid/silica thin film mesophases, films formed from the hybrid bridged silsesquioxane precursor bis(triethoxysilyl)ethane exhibited greater stability toward (both diacyl and monoacyl) lipid removal. Ellipsometric, FTIR, and NMR studies show that the presence of phospholipid suppresses siloxane network formation, while actually promoting condensation reactions in the hybrid material. 1D X-ray scattering and FTIR data were found to be consistent with strong interactions between lipid headgroups and the silica framework.

Original languageEnglish (US)
Pages (from-to)9500-9509
Number of pages10
JournalLangmuir
Volume25
Issue number16
DOIs
StatePublished - Aug 18 2009
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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