Characterization of microglial responses to Staphylococcus aureus: Effects on cytokine, costimulatory molecule, and Toll-like receptor expression

Tammy Kielian; Patrick Mayes; Mark Kielian

doi:10.1016/S0165-5728(02)00216-3

Characterization of microglial responses to Staphylococcus aureus: Effects on cytokine, costimulatory molecule, and Toll-like receptor expression

Tammy Kielian, Patrick Mayes, Mark Kielian

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Microglia participate in innate immune responses in the central nervous system (CNS). This work demonstrates that microglia can recognize heat-inactivated Staphylococcus aureus and its cell wall product peptidoglycan (PGN) through the elaboration of numerous proinflammatory cytokines and chemokines. Microglia also exhibited S. aureus bactericidal activity. Microglia constitutively expressed low levels of Toll-like receptor 1 (TLR1), TLR2, TLR6, and CD14, all of which were enhanced following S. aureus exposure. Activation of resident microglia by S. aureus may serve to amplify the CNS antibacterial immune response through the release of cytokines, chemokines, and induction of bactericidal activity.

Original language	English (US)
Pages (from-to)	86-99
Number of pages	14
Journal	Journal of Neuroimmunology
Volume	130
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(02)00216-3
State	Published - Sep 2002
Externally published	Yes

Keywords

CD14
Chemokine
Cytokine
Microglia
Staphylococcus aureus
Toll-like receptors

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/S0165-5728(02)00216-3

Cite this

@article{48b7f57cf41b4bfc8d40911acbd1c6d6,

title = "Characterization of microglial responses to Staphylococcus aureus: Effects on cytokine, costimulatory molecule, and Toll-like receptor expression",

abstract = "Microglia participate in innate immune responses in the central nervous system (CNS). This work demonstrates that microglia can recognize heat-inactivated Staphylococcus aureus and its cell wall product peptidoglycan (PGN) through the elaboration of numerous proinflammatory cytokines and chemokines. Microglia also exhibited S. aureus bactericidal activity. Microglia constitutively expressed low levels of Toll-like receptor 1 (TLR1), TLR2, TLR6, and CD14, all of which were enhanced following S. aureus exposure. Activation of resident microglia by S. aureus may serve to amplify the CNS antibacterial immune response through the release of cytokines, chemokines, and induction of bactericidal activity.",

keywords = "CD14, Chemokine, Cytokine, Microglia, Staphylococcus aureus, Toll-like receptors",

author = "Tammy Kielian and Patrick Mayes and Mark Kielian",

note = "Funding Information: The authors would like to thank Dr. Paul Drew for critical reading of the manuscript. This work was supported by NIH RO1 NS40730 (to T.K.).",

year = "2002",

month = sep,

doi = "10.1016/S0165-5728(02)00216-3",

language = "English (US)",

volume = "130",

pages = "86--99",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Characterization of microglial responses to Staphylococcus aureus

T2 - Effects on cytokine, costimulatory molecule, and Toll-like receptor expression

AU - Kielian, Tammy

AU - Mayes, Patrick

AU - Kielian, Mark

N1 - Funding Information: The authors would like to thank Dr. Paul Drew for critical reading of the manuscript. This work was supported by NIH RO1 NS40730 (to T.K.).

PY - 2002/9

Y1 - 2002/9

N2 - Microglia participate in innate immune responses in the central nervous system (CNS). This work demonstrates that microglia can recognize heat-inactivated Staphylococcus aureus and its cell wall product peptidoglycan (PGN) through the elaboration of numerous proinflammatory cytokines and chemokines. Microglia also exhibited S. aureus bactericidal activity. Microglia constitutively expressed low levels of Toll-like receptor 1 (TLR1), TLR2, TLR6, and CD14, all of which were enhanced following S. aureus exposure. Activation of resident microglia by S. aureus may serve to amplify the CNS antibacterial immune response through the release of cytokines, chemokines, and induction of bactericidal activity.

AB - Microglia participate in innate immune responses in the central nervous system (CNS). This work demonstrates that microglia can recognize heat-inactivated Staphylococcus aureus and its cell wall product peptidoglycan (PGN) through the elaboration of numerous proinflammatory cytokines and chemokines. Microglia also exhibited S. aureus bactericidal activity. Microglia constitutively expressed low levels of Toll-like receptor 1 (TLR1), TLR2, TLR6, and CD14, all of which were enhanced following S. aureus exposure. Activation of resident microglia by S. aureus may serve to amplify the CNS antibacterial immune response through the release of cytokines, chemokines, and induction of bactericidal activity.

KW - CD14

KW - Chemokine

KW - Cytokine

KW - Microglia

KW - Staphylococcus aureus

KW - Toll-like receptors

UR - http://www.scopus.com/inward/record.url?scp=0036709090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036709090&partnerID=8YFLogxK

U2 - 10.1016/S0165-5728(02)00216-3

DO - 10.1016/S0165-5728(02)00216-3

M3 - Article

C2 - 12225891

AN - SCOPUS:0036709090

SN - 0165-5728

VL - 130

SP - 86

EP - 99

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Characterization of microglial responses to Staphylococcus aureus: Effects on cytokine, costimulatory molecule, and Toll-like receptor expression

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this