Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998

A. Carattoli; F. Tosini; W. P. Giles; M. E. Rupp; S. H. Hinrichs; F. J. Angulo; T. J. Barrett; P. D. Fey

doi:10.1128/AAC.46.5.1269-1272.2002

Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998

A. Carattoli, F. Tosini, W. P. Giles, M. E. Rupp, S. H. Hinrichs, F. J. Angulo, T. J. Barrett, P. D. Fey

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133 Scopus citations

Abstract

Sequencing of DNA from 15 expanded-spectrum cephalosporin (e.g., ceftriaxone)-resistant Salmonella isolates obtained in the United States revealed that resistance to ceftriaxone in all isolates was mediated by cmy-2. Hybridization patterns revealed three plasmid structures containing cmy-2 in these 15 isolates. These data suggest that the spread of cmy-2 among Salmonella strains is occurring through mobilization of the cmy-2 gene into different plasmid backbones and consequent horizontal transfer by conjugation.

Original language	English (US)
Pages (from-to)	1269-1272
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	46
Issue number	5
DOIs	https://doi.org/10.1128/AAC.46.5.1269-1272.2002
State	Published - 2002

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Carattoli, A., Tosini, F., Giles, W. P., Rupp, M. E., Hinrichs, S. H., Angulo, F. J., Barrett, T. J., & Fey, P. D. (2002). Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998. Antimicrobial Agents and Chemotherapy, 46(5), 1269-1272. https://doi.org/10.1128/AAC.46.5.1269-1272.2002

Carattoli, A, Tosini, F, Giles, WP, Rupp, ME , Hinrichs, SH, Angulo, FJ, Barrett, TJ & Fey, PD 2002, 'Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998', Antimicrobial Agents and Chemotherapy, vol. 46, no. 5, pp. 1269-1272. https://doi.org/10.1128/AAC.46.5.1269-1272.2002

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AU - Tosini, F.

AU - Giles, W. P.

AU - Rupp, M. E.

AU - Hinrichs, S. H.

AU - Angulo, F. J.

AU - Barrett, T. J.

AU - Fey, P. D.

PY - 2002

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AB - Sequencing of DNA from 15 expanded-spectrum cephalosporin (e.g., ceftriaxone)-resistant Salmonella isolates obtained in the United States revealed that resistance to ceftriaxone in all isolates was mediated by cmy-2. Hybridization patterns revealed three plasmid structures containing cmy-2 in these 15 isolates. These data suggest that the spread of cmy-2 among Salmonella strains is occurring through mobilization of the cmy-2 gene into different plasmid backbones and consequent horizontal transfer by conjugation.

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Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998

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