Characterization of retinal structure and diagnosis of peripheral acquired retinoschisis using high-resolution ultrasound B-scan

Aniruddha Agarwal, Shan Fan, Alessandro Invernizzi, Diana V. Do, Quan Dong Nguyen, Nathan V. Harms, Yasir J. Sepah

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Purpose: The purpose of the study was to report the ability of high-resolution ultrasonography (USG) B-Scan in differentiating between acquired retinoschisis (RS) and retinal detachment (RD), and to compare the findings with spectral-domain optical coherence tomography (SD-OCT). Methods: Patients with acquired peripheral RS and RD undergoing imaging with high-resolution B-scan USG and SD-OCT were included in the study. Descriptive analysis was performed on the images obtained by high-resolution B-scan USG to identify various retinal interfaces. The findings were correlated with those obtained using the SD-OCT images. Results: Six eyes of five patients (two males) with RS and seven eyes of four patients (three males) with RD were included in the study. In all eyes of patients with RS, the outer retina demonstrated the presence of two hyper-reflective lines corresponding to the interfaces of the outer plexiform layer (OPL) and the retinal pigment epithelium (OPL). Eyes diagnosed with RD demonstrated two hyper-reflective lines in the detached portion, corresponding to the nerve fiber layer and OPL interfaces, whereas the attached portion demonstrated the presence of the third hyper-reflective interface, i.e., RPE. These findings correlated well with SD-OCT. Conclusions: Analysis of retinal interfaces on high-resolution USG B-scan may allow precise differentiation of acquired RS from RD by identification of various retinal layers. These findings correlate well with SD-OCT.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number1
StatePublished - Jan 1 2016


  • High-resolution ultrasound
  • Multimodal imaging
  • Optical coherence tomography
  • Retinal detachment
  • Retinoschisis
  • Wide-field fundus photography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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