Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtA

Peter R. Kraus, Amy F. Hofmann, Steven D. Harris

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The 14-3-3 family of proteins function as small adaptors that facilitate a diverse array of cellular processes by mediating specific protein interactions. One such process is the DNA damage checkpoint, where these proteins prevent inappropriate activation of cyclin-dependent kinases. The filamentous fungus Aspergillus nidulans possesses a highly conserved 14-3-3 homologue (artA) that may function in an analogous manner to prevent septum formation. However, instead of blocking septation, over-expression of artA causes a severe delay in the polarization of conidiospores. This observation suggests that these proteins play an important role in hyphal morphogenesis.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalFEMS Microbiology Letters
Volume210
Issue number1
DOIs
StatePublished - Apr 23 2002

Keywords

  • 14-3-3
  • Aspergillus
  • Cell cycle checkpoint
  • Fungal
  • Polarity
  • Septation

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtA'. Together they form a unique fingerprint.

  • Cite this