Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtA

Peter R. Kraus, Amy F. Hofmann, Steven D. Harris

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The 14-3-3 family of proteins function as small adaptors that facilitate a diverse array of cellular processes by mediating specific protein interactions. One such process is the DNA damage checkpoint, where these proteins prevent inappropriate activation of cyclin-dependent kinases. The filamentous fungus Aspergillus nidulans possesses a highly conserved 14-3-3 homologue (artA) that may function in an analogous manner to prevent septum formation. However, instead of blocking septation, over-expression of artA causes a severe delay in the polarization of conidiospores. This observation suggests that these proteins play an important role in hyphal morphogenesis.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalFEMS Microbiology Letters
Issue number1
StatePublished - Apr 23 2002


  • 14-3-3
  • Aspergillus
  • Cell cycle checkpoint
  • Fungal
  • Polarity
  • Septation

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics


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