Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

Rick A. Bevins; Timothy A. Delzer; Michael T. Bardo

doi:10.1016/0091-3057(95)02071-3

Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

Rick A. Bevins, Timothy A. Delzer, Michael T. Bardo

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D₃ agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

Original language	English (US)
Pages (from-to)	695-699
Number of pages	5
Journal	Pharmacology Biochemistry and Behavior
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(95)02071-3
State	Published - Mar 1996
Externally published	Yes

Keywords

7-Hydroxy-N,N-di-n-propyl-2-aminotetralin
7-OH-DPAT
Amphetamine
Cocaine
D receptor
D receptor
Dopamine
Reward
Saccharin taste aversion
Sigma receptor

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(95)02071-3

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title = "Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats",

abstract = "Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.",

keywords = "7-Hydroxy-N,N-di-n-propyl-2-aminotetralin, 7-OH-DPAT, Amphetamine, Cocaine, D receptor, D receptor, Dopamine, Reward, Saccharin taste aversion, Sigma receptor",

author = "Bevins, {Rick A.} and Delzer, {Timothy A.} and Bardo, {Michael T.}",

note = "Funding Information: This work was funded by United States Public Health Service Grant DA05623 to R. A. Bevins and Grants DA05312 and DA07746 to M. T. Bardo. We thank Patricia Robinet and Joanne Valone for comments on an earlier version of this manuscript.",

year = "1996",

month = mar,

doi = "10.1016/0091-3057(95)02071-3",

language = "English (US)",

volume = "53",

pages = "695--699",

journal = "Pharmacology Biochemistry and Behavior",

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T1 - Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

AU - Bevins, Rick A.

AU - Delzer, Timothy A.

AU - Bardo, Michael T.

N1 - Funding Information: This work was funded by United States Public Health Service Grant DA05623 to R. A. Bevins and Grants DA05312 and DA07746 to M. T. Bardo. We thank Patricia Robinet and Joanne Valone for comments on an earlier version of this manuscript.

PY - 1996/3

Y1 - 1996/3

N2 - Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

AB - Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

KW - 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin

KW - 7-OH-DPAT

KW - Amphetamine

KW - Cocaine

KW - D receptor

KW - Dopamine

KW - Reward

KW - Saccharin taste aversion

KW - Sigma receptor

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JO - Pharmacology Biochemistry and Behavior

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IS - 3

ER -

Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

Abstract

Keywords

ASJC Scopus subject areas

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