Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

Rick A. Bevins, Timothy A. Delzer, Michael T. Bardo

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

Original languageEnglish (US)
Pages (from-to)695-699
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume53
Issue number3
DOIs
StatePublished - Mar 1996

Keywords

  • 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin
  • 7-OH-DPAT
  • Amphetamine
  • Cocaine
  • D receptor
  • D receptor
  • Dopamine
  • Reward
  • Saccharin taste aversion
  • Sigma receptor

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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