Characterization of the human HOX 7 cDNA and identification of polymorphic markers

B. J. Padanilam, H. S. Stadler, K. A. Mills, L. B. Mcleod, M. Solursh, B. Lee, F. Ramirez, K. H. Buetow, J. C. Murray

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified Mboll and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.

Original languageEnglish (US)
Pages (from-to)407-410
Number of pages4
JournalHuman Molecular Genetics
Issue number6
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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