Abstract
The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridgehead carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.
Original language | English (US) |
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Pages (from-to) | 1555-1558 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 18 |
Issue number | 5 |
DOIs | |
State | Published - Mar 1 2008 |
Keywords
- 1,2,4-Trioxolane
- Antimalarial
- CYP450
- Ozonide
- Synthetic peroxide
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry