Characterization of tumor angiogenesis with dynamic contrast-enhanced MRI and biodegradable macromolecular contrast agents in mice

Yi Feng, Eun Kee Jeong, Aaron M. Mohs, Lyska Emerson, Zheng Rong Lu

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The efficacy of polydisulfide-based biodegradable macromolecular contrast agents for characterizing tumor angiogenesis was investigated in a mouse model using dynamic contrast-enhanced MRI (DCE-MRI). Biodegradable macromolecular MRI contrast agents, gadopentetate dimeglumine (Gd-DTPA) cystamine copolymers (GDCC), and Gd-DTPA cystine copolymers (GDCP), with molecular weights of 20 and 70 kDa were used in the study. Gadodiamide (Gd [DTPA-BMA]) and albumin labeled with Gd-DTPA [albumin-(Gd-DTPA)] were used as the controls. The DCE-MRI studies were performed in nude mice bearing prostate tumor xenografts from the MDA-PCa-2b cell line. Tumor angiogenic kinetic parameters, including endothelial transfer coefficient (KPS), fractional tumor plasma volume (f PV), and permeability surface area product (PS), were estimated from the DCE-MRI data using a two-compartment model. The KPS and f PV values estimated by the biodegradable macromolecular contrast agents were between those estimated by Gd(DTPA-BMA) and albumin-(Gd-DTPA). The parameters estimated by the agent with a slow degradation rate and high molecular weight, GDCP-70 (KPS = 2.09 ± 0.50 ml/min/100 cc and fPV = 0.075 ± 0.021), were closer to those by albumin-(Gd-DTPA) (KPS = 1.43 ± 0.64 ml/min/100 cc and f PV = 0.044 ± 0.007) than by other agents with relatively low molecular weight or rapid degradation rate. The polydisulfide-based biodegradable macromolecular contrast agents are promising for characterizing tumor vascularity and angiogenesis with DCE-MRI.

Original languageEnglish (US)
Pages (from-to)1347-1352
Number of pages6
JournalMagnetic Resonance in Medicine
Volume60
Issue number6
DOIs
StatePublished - Dec 1 2008

Keywords

  • Biodegradable macromolecular contrast agent
  • DCE-MRI
  • GDCC
  • GDCP
  • Gd-DTPA cystamine copolymers
  • Gd-DTPA cystine copolymers
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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