Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1 → q13.4

J. Dai, Y. Li, C. Ji, F. Jin, Z. Zheng, X. Wang, X. Sun, X. Xu, S. Gu, Y. Xie, Y. Mao

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This study reports the cloning and characterization of two novel human zinc finger protein cDNAs (ZNF460 and ZNF461) from a fetal brain cDNA library. The ZNF460 cDNA is 3,135 bp in length encoding a 562-amino-acid polypeptide and the ZNF461 cDNA is 2,548 bp encoding a 563-amino-acid protein. Both of the proteins contain a KRAB A+B box and eleven C2H2 type zinc finger motifs. ZNF461 shows high similarity with the rat GIOT-1 gene (Giot1). The ZNF460 gene mapped to 19q13.4 with 3 exons, and ZNF461 mapped to 19q13.1 with 6 exons. Both of the two genes are ubiquitously expressed in normal human tissues and the abundance of the ZNF460 mRNA is relatively low.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalCytogenetic and Genome Research
Volume103
Issue number1-2
DOIs
StatePublished - 2003
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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