Chemical Modification of Human Plasminogen

Fang Liang, Yi Hui Wu, Hai Shi Cao, Hui Yun Guo, Lan Ying Liu, Hong Sun, Wei Jin Chen, Shu Ying Liu

Research output: Contribution to journalArticlepeer-review


The chemical modification of human plasminogen (HPg) was studied with NAI, 1,2-cyclohexanodine, Ch-T, and EDC as the modification reagents on its Tyr, Arg, Met and carboxyl groups. The results indicate that Tyr and Arg residues are not activity dependent groups, while Met and carboxyl groups played an important role on HPg's activity. The kinetic analysis demonstrates that one Met residue and two carboxyl groups are essential for HPg's activity.

Original languageEnglish (US)
Pages (from-to)580
Number of pages1
JournalKao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
Issue number4
StatePublished - Apr 2001
Externally publishedYes


  • Carboxyl group
  • Chemical modification
  • Human Plasminogen
  • Methionine

ASJC Scopus subject areas

  • Chemistry(all)


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