Chemical Modification of Human Plasminogen

Fang Liang; Yi Hui Wu; Hai Shi Cao; Hui Yun Guo; Lan Ying Liu; Hong Sun; Wei Jin Chen; Shu Ying Liu

Chemical Modification of Human Plasminogen

Fang Liang, Yi Hui Wu, Hai Shi Cao, Hui Yun Guo, Lan Ying Liu, Hong Sun, Wei Jin Chen, Shu Ying Liu

Research output: Contribution to journal › Article › peer-review

Abstract

The chemical modification of human plasminogen (HPg) was studied with NAI, 1,2-cyclohexanodine, Ch-T, and EDC as the modification reagents on its Tyr, Arg, Met and carboxyl groups. The results indicate that Tyr and Arg residues are not activity dependent groups, while Met and carboxyl groups played an important role on HPg's activity. The kinetic analysis demonstrates that one Met residue and two carboxyl groups are essential for HPg's activity.

Original language	English (US)
Pages (from-to)	580
Number of pages	1
Journal	Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
Volume	22
Issue number	4
State	Published - Apr 2001
Externally published	Yes

Keywords

Carboxyl group
Chemical modification
Human Plasminogen
Methionine

ASJC Scopus subject areas

General Chemistry

Cite this

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title = "Chemical Modification of Human Plasminogen",

abstract = "The chemical modification of human plasminogen (HPg) was studied with NAI, 1,2-cyclohexanodine, Ch-T, and EDC as the modification reagents on its Tyr, Arg, Met and carboxyl groups. The results indicate that Tyr and Arg residues are not activity dependent groups, while Met and carboxyl groups played an important role on HPg's activity. The kinetic analysis demonstrates that one Met residue and two carboxyl groups are essential for HPg's activity.",

keywords = "Carboxyl group, Chemical modification, Human Plasminogen, Methionine",

author = "Fang Liang and Wu, {Yi Hui} and Cao, {Hai Shi} and Guo, {Hui Yun} and Liu, {Lan Ying} and Hong Sun and Chen, {Wei Jin} and Liu, {Shu Ying}",

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T1 - Chemical Modification of Human Plasminogen

AU - Liang, Fang

AU - Wu, Yi Hui

AU - Cao, Hai Shi

AU - Guo, Hui Yun

AU - Liu, Lan Ying

AU - Sun, Hong

AU - Chen, Wei Jin

AU - Liu, Shu Ying

PY - 2001/4

Y1 - 2001/4

N2 - The chemical modification of human plasminogen (HPg) was studied with NAI, 1,2-cyclohexanodine, Ch-T, and EDC as the modification reagents on its Tyr, Arg, Met and carboxyl groups. The results indicate that Tyr and Arg residues are not activity dependent groups, while Met and carboxyl groups played an important role on HPg's activity. The kinetic analysis demonstrates that one Met residue and two carboxyl groups are essential for HPg's activity.

AB - The chemical modification of human plasminogen (HPg) was studied with NAI, 1,2-cyclohexanodine, Ch-T, and EDC as the modification reagents on its Tyr, Arg, Met and carboxyl groups. The results indicate that Tyr and Arg residues are not activity dependent groups, while Met and carboxyl groups played an important role on HPg's activity. The kinetic analysis demonstrates that one Met residue and two carboxyl groups are essential for HPg's activity.

KW - Carboxyl group

KW - Chemical modification

KW - Human Plasminogen

KW - Methionine

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JO - Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities

JF - Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities

IS - 4

ER -

Chemical Modification of Human Plasminogen

Abstract

Keywords

ASJC Scopus subject areas

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