Chemistry and biological activity of AAL toxins

Carl K. Winter, David G. Gilchrist, Martin B. Dickman, Clinton Jones

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

AAL toxins and fumonisins comprise a family of highly reactive, chemically related mycotoxins that disrupt cellular homeostasis in both plant and animal tissues. Two critical issues to resolve are the detection of the entire family in food matrices and the mode of cellular disruption. Analysis of the entire set of chemical congeners in food matrices is difficult but has been achieved by a combination of different HPLC and mass spectrometry strategies. The mode of cellular disruption is unknown but likely involves changes associated with the inhibition of ceramide synthase in both plants and animals. Toxin treated cells exhibit morphological and biochemical changes characteristic of apoptosis. Further evaluation of the specific genetic and biochemical changes that occur during toxin-induced cell death may aid in understanding the mole of the action of these mycotoxins.

Original languageEnglish (US)
Pages (from-to)307-316
Number of pages10
JournalAdvances in experimental medicine and biology
Volume392
Publication statusPublished - Jan 1 1996

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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Winter, C. K., Gilchrist, D. G., Dickman, M. B., & Jones, C. (1996). Chemistry and biological activity of AAL toxins. Advances in experimental medicine and biology, 392, 307-316.