Chemoenzymatic synthesis of Park's nucleotide: toward the development of high-throughput screening for MraY inhibitors

Michio Kurosu, Sebabrata Mahapatra, Prabagaran Narayanasamy, Dean C. Crick

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

An efficient chemoenzymatic synthesis of UDP-N-acetylmuramyl-l-alanyl-γ-d-glutamyl-meso-diaminopimelyl-d-alanyl-d-alanine (Park's nucleotide) is reported. UDP-MurNAc is efficiently synthesized by a minimum number of protecting strategies. One-pot amino acid ligation reactions catalyzed by MurC, D, E, and F enzymes are amenable to scale-up production.

Original languageEnglish (US)
Pages (from-to)799-803
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number5
DOIs
StatePublished - Jan 29 2007

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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