Chiasma-based models of multilocus recombination: Increased power for exclusion mapping and gene ordering

David E. Goldgar, Pamela R. Fain, William J. Kimberling

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Cytological evidence indicates that the number of chiasmata which can occur on any given chromosome arm is limited. In this paper a Monte-Carlo simulation study is used to compare the power of a model of multilocus recombination parameterized in terms of chromosome-specific chiasma distributions with the traditional model parameterized by recombination fractions in adjacent intervals. Two specific gene mapping problems are considered: excluding a test locus from a given chromosome map and ordering a test locus with respect to a fixed map of syntenic marker loci. We show that the chiasma-based models require significantly fewer observations to exclude or order a test locus and that they are quite robust to errors in specifying the underlying true chiasma distribution.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalGenomics
Volume5
Issue number2
DOIs
StatePublished - Aug 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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