Chikungunya virus: Pathophysiology, mechanism, and modeling

Vaishnavi K. Ganesan, Bin Duan, St Patrick Reid

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, is recurring in epidemic waves. In the past decade and a half, the disease has resurged in several countries around the globe, with outbreaks becoming increasingly severe. Though CHIKV was first isolated in 1952, there remain significant gaps in knowledge of CHIKV biology, pathogenesis, transmission, and mechanism. Diagnosis is largely simplified and based on symptoms, while treatment is supportive rather than curative. Here we present an overview of the disease, the challenges that lie ahead for future research, and what directions current studies are headed towards, with emphasis on improvement of current animal models and potential use of 3D models.

Original languageEnglish (US)
Article number368
Issue number12
StatePublished - Dec 2017


  • 3D organoid
  • Arboviruses
  • Pathogenesis
  • Vaccine

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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