Childhood anaplastic large cell lymphoma has a high incidence of ALK gene rearrangement as determined by immunohistochemical staining and fluorescent in situ hybridisation: A genetic and pathological correlation

Sherrie L. Perkins, Diane Pickering, Eric J. Lowe, David Zwick, Minnie Abromowitch, Ginny Davenport, Mitchell S. Cairo, Warren G. Sanger

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Anaplastic large cell lymphoma (ALCL) comprises 10-15% of childhood non-Hodgkin lymphomas (NHL). Systemic ALCL is highly associated with anaplastic lymphoma kinase (ALK) gene translocations with over-expression of ALK protein. We studied ALK rearrangements using fluorescence in situ hybridisation (FISH) and ALK immunohistochemical staining in 43 paediatric systemic ALCLs. FISH (performed on 35 cases) identified a translocation in 29 cases (83%). Immunohistochemistry identified ALK over-expression in 42/43 cases (97%) with the single ALK-negative case demonstrating an ALK rearrangement by FISH, indicating 100% incidence of ALK translocations.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
JournalBritish Journal of Haematology
Volume131
Issue number5
DOIs
StatePublished - Dec 2005

Keywords

  • ALK
  • Anaplastic large cell lymphoma
  • Fluorescent in situ hybridisation
  • Immunochemistry
  • Paediatric non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Hematology

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