Childhood leukemia - lymphoma. Heterogeneity of phenotypes and prognoses

J. H. Kersey, T. W. LeBien, R. Hurwitz, M. E. Nesbit, K. J. Gajl-Peczalska, D. Hammond, D. R. Miller, P. F. Coccia, S. Leikin

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24 Scopus citations


Results are reported on 724 children and adolescents with acute leukemia-lymphoma. One hundred patients had immunologic marker analysis that defined the major phenotypic groups, i.e., T-cell, B-cell (Burkitt), myeloid, and the most frequent form, non-T, non-B 'common' or 'undifferentiated' acute leukemia. Pre-T, pre-B, and 'null' leukemias are included in the latter group. Response to therapy and survival was best in non-T, non-B acute lymphocytic leukemia, intermediate in T-cell disease, and worst in B-cell (Burkitt) disease. Additional factors resulting in decreased survival include elevated peripheral leukocyte count, presence of enlarged nodes, less depression of hemoglobin and platelets, and age greater than 7 years (all associated with 'lymphomatous' disease). Other factors resulting in decreased survival include age under 3 years and depression of serum immunoglobulins. Definition of the heterogeneity of childhood leukemia-lymphoma dictates differing forms of therapy for the various types of these diseases.

Original languageEnglish (US)
Pages (from-to)746-752
Number of pages7
JournalAmerican journal of clinical pathology
Issue number4 Suppl.
StatePublished - 1979

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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