Children with Cerebral Palsy Hyper-Gate Somatosensory Stimulations of the Foot

Max J. Kurz, Alex I. Wiesman, Nathan M. Coolidge, Tony W. Wilson

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


We currently have a substantial knowledge gap in our understanding of the neurophysiological underpinnings of the sensory perception deficits often reported in the clinic for children with cerebral palsy (CP). In this investigation, we have begun to address this knowledge gap by using magnetoencephalography (MEG) brain imaging to evaluate the sensory gating of neural oscillations in the somatosensory cortices. A cohort of children with CP (Gross Motor Function Classification System II-III) and typically developing children underwent paired-pulse electrical stimulation of the tibial nerve during MEG. Advanced beamforming methods were used to image significant oscillatory responses, and subsequently the time series of neural activity was extracted from peak voxels. Our experimental results showed that somatosensory cortical oscillations (10-75 Hz) were weaker in the children with CP for both stimulations. Despite this reduction, the children with CP actually exhibited a hyper-gating response to the second, redundant peripheral stimulation applied to the foot. These results have further established the nexus of the cortical somatosensory processing deficits that are likely responsible for the degraded sensory perceptions reported in the clinic for children with CP.

Original languageEnglish (US)
Pages (from-to)2431-2438
Number of pages8
JournalCerebral Cortex
Issue number7
StatePublished - Jul 1 2018


  • MEG
  • cortical oscillations
  • paired-pulse stimulation
  • sensory

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Children with Cerebral Palsy Hyper-Gate Somatosensory Stimulations of the Foot'. Together they form a unique fingerprint.

Cite this