Chiral relay in enantioselective conjugate radical additions using pyrazolidinone templates. How does metal geometry impact selectivity?

Mukund P. Sibi, Narayanasamy Prabagaran

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

A novel class of achiral templates containing fluxional groups has been evaluated in conjugate radical additions. Magnesium and copper Lewis acids provide high enantioselectivity (>90% ee) for radical additions. The impact of the metal geometry on enantioselectivity using relay templates has also been assessed.

Original languageEnglish (US)
Pages (from-to)2421-2424
Number of pages4
JournalSynlett
Issue number13
DOIs
StatePublished - Nov 3 2004

Keywords

  • Chiral Lewis acid
  • Conjugate additions
  • Enantioselectivity amplification
  • Pyrazolidinones
  • Radical reactions
  • Relay

ASJC Scopus subject areas

  • Organic Chemistry

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