Chitosan-based inverse opals: Three-dimensional scaffolds with uniform pore structures for cell culture

Sung Wook Choi, Jingwei Xie, Younan Xia

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

A technique for fabricating chitosan inverse opal three-dimensional scaffolds characterized by a biodegradable material, uniform pore size, well-controlled interconnectivity, and nanofibrous texture on the wall surface, was described. A uniform poly(caprolactone) (PCL) microsphere, prepared using a simple fluidic device, was used as a template. The results show that by placing the ccp lattice formed from the PCL microspheres, in an oven heated at 45°C for 50 min, a robust ccp lattice in the form of a pellet without changing the surface morphology of the microspheres could be obtained. The open and ordered pore structure throughout the scaffold allows cells to easily penetrate into the scaffold, facilitate the exchange of nutrient and metabolite waste, and promote in vivo vascularization.

Original languageEnglish (US)
Pages (from-to)2997-3001
Number of pages5
JournalAdvanced Materials
Volume21
Issue number29
DOIs
StatePublished - Aug 7 2009

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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