Cholecystokinin expression in the developing and regenerating pancreas and intestine

G. Liu, S. V. Pakala, D. Gu, T. Krahl, L. Mocnik, N. Sarvetnick

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


In developmental terms, the endocrine system of neither the gut nor the pancreatic islets has been characterized fully. Little is known about the involvement of cholecystokinin (CCK), a gut hormone, involved in regulating the secretion of pancreatic hormones, and pancreatic growth. Here, we tracked CCK-expressing cells in the intestines and pancreata of normal mice (BALB/c), Non Obese Diabetic (NOD) mice and interferon (IFN)-γ transgenic mice, which exhibit pancreatic regeneration, during embryonic development, the postnatal period and adulthood. We also questioned whether IFN-γ influences the expression of CCK. The results from embryonic day 16 showed that all three strains had CCK in the acinar region of pancreata, and specifically in α cells that also expressed glucagon. However, in adulthood only BALB/c and NOD mice continued this pattern. By contrast, in IFN-γ transgenic mice, CCK expression was suppressed from birth to 3 months of age in the pancreata but not intestines. However, by 5 months of age, CCK expression appeared in the regenerating pancreatic ductal region of IFN-γ transgenic mice. In the intestine, CCK expression persisted from fetus to adulthood and was not influenced by IFN-γ. Intestinal cells expressing CCK did not co-express glucagon, suggesting that these cells are phenotypically distinct from CCK-expressing cells in the pancreatic islets, and the effect of IFN-γ on CCK varies depending upon the cytokine's specific microenvironment.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalJournal of Endocrinology
Issue number2
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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