Choosing a pediatric recipient for orthotopic liver transplantation

J. Jeffrey Malatack, Daniel J. Schaid, Andrew H. Urbach, J. Carlton Gartner, Basil J. Zitelli, Howard Rockette, John Fischer, Thomas E. Starzl, Shunzaburo Iwatsuki, Byers W. Shaw

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Between March 3, 1981, and June 1, 1984, 216 children were evaluated for orthotopic liver transplantation. Of the 216 patients, 117 (55%) had recelved at least one liver transplant by June 1, 1985. Fifty-five (25%) died before transplantation. The 117 patients who received transplants were grouped according to severity of disease and degree of general decompensation at the time of transplantation. The severity of a patient's medical condition with the possible exception of deep hepatic coma, did not predict outcome following orthotopic liver transplantation. Seventy variables were assessed at the time of the evaluation. Twenty-three of the 70 variables were found to have prognostic significance with regard to death from progressive liver disease before transplantation. These 23 variables were Incorporated into a multivariate model to provide a means of determining the relative risk of death among pediatric patients with end-stage liver disease. This information may allow more informed selection of candidates awaiting liver transplantation.

Original languageEnglish (US)
Pages (from-to)479-489
Number of pages11
JournalThe Journal of Pediatrics
Volume111
Issue number4
DOIs
StatePublished - Oct 1987

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Malatack, J. J., Schaid, D. J., Urbach, A. H., Gartner, J. C., Zitelli, B. J., Rockette, H., Fischer, J., Starzl, T. E., Iwatsuki, S., & Shaw, B. W. (1987). Choosing a pediatric recipient for orthotopic liver transplantation. The Journal of Pediatrics, 111(4), 479-489. https://doi.org/10.1016/S0022-3476(87)80105-1