Chromatin remodeling: A novel mechanism of psychotropic drug action

Samuel S. Newton, Ronald S. Duman

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Regulation of gene expression is known to contribute to the long-term adaptations underlying the effects of psychotropic drugs, including the actions of antidepressants and drugs of abuse in behavioral models. However, the precise molecular events that are required for modification of chromatin and that underlie gene repression or activation have not been elucidated. Recent reports, including the article by Cassel et al. (p. 487) in this issue of Molecular Pharmacology, address this question and demonstrate that psychotropic drugs modify specific methyl-CpG-binding proteins that control histone acetylation and gene expression.

Original languageEnglish (US)
Pages (from-to)440-443
Number of pages4
JournalMolecular pharmacology
Issue number2
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology


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