Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature

Sarah J. Swarts, James R. Neff, Marilu Nelson, Sonny Johansson, Julia A. Bridge

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

In this study, cytogenetic analysis of two low-grade chondrosarcomas revealed relatively simple chromosomal complements with structural rearrangements involving chromosomes 1, 6, and 12 [46,XY,add(16)(q24)[3]/46,XY,t(1;20)(q21;q11),t(6;17)(q23;q23)[3]/46,XY,t(4;1 4)(q12;q24),t(5;6)(q12;p21) [2] and 45,XY,t(12;16)(q13;q24),- 14[17]/44,idem,add(4)(p16),-17,[2] respectively]. Previously published reports of chondrosarcoma have revealed structural abnormalities of chromosomes 1, 6, 9, 12, and 15 as common. Also, a correlation between the simplicity or complexity of the abnormalities seen and histologic grade has been suggested. The findings of the current study support these earlier observations.

Original languageEnglish (US)
Pages (from-to)126-130
Number of pages5
JournalCancer genetics and cytogenetics
Volume98
Issue number2
DOIs
StatePublished - Oct 15 1997

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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