Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature

Sarah J. Swarts; James R. Neff; Marilu Nelson; Sonny Johansson; Julia A. Bridge

doi:10.1016/S0165-4608(96)00425-6

Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature

Sarah J. Swarts, James R. Neff, Marilu Nelson, Sonny Johansson, Julia A. Bridge

Pathology & Microbiology

Research output: Contribution to journal › Article › peer-review

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Abstract

In this study, cytogenetic analysis of two low-grade chondrosarcomas revealed relatively simple chromosomal complements with structural rearrangements involving chromosomes 1, 6, and 12 [46,XY,add(16)(q24)[3]/46,XY,t(1;20)(q21;q11),t(6;17)(q23;q23)[3]/46,XY,t(4;1 4)(q12;q24),t(5;6)(q12;p21) [2] and 45,XY,t(12;16)(q13;q24),- 14[17]/44,idem,add(4)(p16),-17,[2] respectively]. Previously published reports of chondrosarcoma have revealed structural abnormalities of chromosomes 1, 6, 9, 12, and 15 as common. Also, a correlation between the simplicity or complexity of the abnormalities seen and histologic grade has been suggested. The findings of the current study support these earlier observations.

Original language	English (US)
Pages (from-to)	126-130
Number of pages	5
Journal	Cancer genetics and cytogenetics
Volume	98
Issue number	2
DOIs	https://doi.org/10.1016/S0165-4608(96)00425-6
State	Published - Oct 15 1997

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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title = "Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature",

abstract = "In this study, cytogenetic analysis of two low-grade chondrosarcomas revealed relatively simple chromosomal complements with structural rearrangements involving chromosomes 1, 6, and 12 [46,XY,add(16)(q24)[3]/46,XY,t(1;20)(q21;q11),t(6;17)(q23;q23)[3]/46,XY,t(4;1 4)(q12;q24),t(5;6)(q12;p21) [2] and 45,XY,t(12;16)(q13;q24),- 14[17]/44,idem,add(4)(p16),-17,[2] respectively]. Previously published reports of chondrosarcoma have revealed structural abnormalities of chromosomes 1, 6, 9, 12, and 15 as common. Also, a correlation between the simplicity or complexity of the abnormalities seen and histologic grade has been suggested. The findings of the current study support these earlier observations.",

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AU - Neff, James R.

AU - Nelson, Marilu

AU - Johansson, Sonny

AU - Bridge, Julia A.

PY - 1997/10/15

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N2 - In this study, cytogenetic analysis of two low-grade chondrosarcomas revealed relatively simple chromosomal complements with structural rearrangements involving chromosomes 1, 6, and 12 [46,XY,add(16)(q24)[3]/46,XY,t(1;20)(q21;q11),t(6;17)(q23;q23)[3]/46,XY,t(4;1 4)(q12;q24),t(5;6)(q12;p21) [2] and 45,XY,t(12;16)(q13;q24),- 14[17]/44,idem,add(4)(p16),-17,[2] respectively]. Previously published reports of chondrosarcoma have revealed structural abnormalities of chromosomes 1, 6, 9, 12, and 15 as common. Also, a correlation between the simplicity or complexity of the abnormalities seen and histologic grade has been suggested. The findings of the current study support these earlier observations.

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Chromosomal abnormalities in low grade chondrosarcoma and a review of the literature

Abstract

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