Chromosomal anomalies in two coexistent myeloproliferative disorders

Apar Kishor Ganti, Anil Potti, Syed A. Mehdi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A 58-year-old male presented with fatigue, tiredness, and pruritus after hot showers and an elevated white blood cell count (20,000/mm3). A diagnosis of polycythemia vera (PV) was made after investigation revealed a low erythropoietin and elevated leukocyte alkaline phosphatase (LAP) score; he was treated with repeated phlebotomies. Two years later he developed elevated white counts again and investigation revealed Philadelphia chromosome positive (19/20 cells) chronic myelocytic leukemia (CML). The karyotype also revealed trisomy 9 in 1 of 20 cells. He was treated with imatinib mesylate and went into clinical, hematologic, cytogenetic, and molecular remission. Repeat chromosomal analysis revealed absence of Philadelphia chromosome and BCR/ABL translocation but presence of trisomy 9. To our knowledge, this is the first reported case of coexisting PV and CML both associated with separate chromosomal abnormalities. This also raises an interesting therapeutic consideration of using concomitant imatinib mesylate and hydroxyurea.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalCancer genetics and cytogenetics
Volume145
Issue number2
DOIs
StatePublished - Sep 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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