Chromosome 6 abnormalities are recurrent in synovial chondromatosis

Emilie P. Buddingh, Pamela Krallman, James R. Neff, Marilu Nelson, Jian Liu, Julia A. Bridge

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Synovial chondromatosis, a lesion composed of multiple nodules of cartilage involving articular or tendon sheath synovial membranes, has traditionally been considered a metaplastic condition. A specific or characteristic chromosomal anomaly has not yet been identified in synovial chondromatosis. Cytogenetic and molecular cytogenetic analyses of three cases of synovial chondromatosis revealed clonal karyotypic abnormalities in all three cases including structural abnormalities of chromosome 6 in two. Anomalies of chromosome 6 have been observed in three of five previously reported synovial chondromatosis cases. These findings support a neoplastic origin for synovial chondromatosis and suggest that chromosome 6 aberrations are recurrent in this lesion.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalCancer genetics and cytogenetics
Volume140
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Buddingh, E. P., Krallman, P., Neff, J. R., Nelson, M., Liu, J., & Bridge, J. A. (2003). Chromosome 6 abnormalities are recurrent in synovial chondromatosis. Cancer genetics and cytogenetics, 140(1), 18-22. https://doi.org/10.1016/S0165-4608(02)00636-2