Chromosome Abnormalities May Correlate with Prognosis in Burkitt/Burkitt-Like Lymphomas of Children and Adolescents: A Report from Children's Cancer Group Study CCG-E08

Mark A. Lones, Warren G. Sanger, Michelle M. Le Beau, Nyla A. Heerema, Richard Sposto, Sherrie L. Perkins, Jonathan Buckley, Marshall E. Kadin, Carl R. Kjeldsberg, Anna Meadows, Stuart Siegel, Jonathan Finlay, Sharon Bergeron, Mitchell S. Cairo

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Among pediatric non-Hodgkin lymphomas, the most frequent type is small noncleaved-cell lymphoma (including Burkitt and Burkitt-like). Specific chromosome abnormalities are associated with prognosis in childhood acute lymphoblastic leukemia (ALL); however, chromosome abnormalities have not been evaluated for prognostic value in pediatric Burkitt and Burkitt-like lymphomas. For Children's Cancer Group protocol CCG-E-08 Etiologic Study of Non-Hodgkin Lymphoma in Childhood, 19 patients were enrolled with cytogenetic analysis of Burkitt or Burkitt-like lymphoma and simultaneously enrolled on treatment protocols CCG-503 or CCG-552. Pathology material and karyotypes at initial diagnosis underwent central review. Demographics included an age range of 2 to 14 years (median 8 years) and a male:female ratio of 14:5. All patients had advanced disease (stages III and IV, or ALL). Disease relapsed in five patients (event-free survival 74%, median follow-up 10.4 years). Chromosome abnormalities were identified in 18 patients (95%) including t(8;14)(q24.1;q32) in 12 (63%); t(8;22)(q24.1;q11.2) in 1 (5%); partial duplication of 1q in 7 (37%); and 13q32 abnormalities in 2 (11%). In patients who had relapses, in addition to the t(8;14)(q24.1;q32), two had abnormalities of 13q32 and two had partial duplication of 1q. CMYC translocations were absent in Burkitt-like lymphomas from all three patients. Burkitt and Burkitt-like lymphomas in children have a high frequency of chromosome abnormalities. Burkitt lymphoma abnormalities often involve CMYC translocations, usually a t(8;14)(q24.1;q32). Additional chromosome abnormalities that involved 13q32 and partial duplication of 1q were associated with poor prognosis. Burkitt-like lymphomas were not associated with CMYC translocations. Further studies are warranted in larger cohorts of children and adolescents with Burkitt and Burkitt-like lymphomas.

Original languageEnglish (US)
Pages (from-to)169-178
Number of pages10
JournalJournal of Pediatric Hematology/Oncology
Issue number3
StatePublished - Mar 2004
Externally publishedYes


  • Adolescence
  • B-cell lymphoma
  • Child
  • Chromosome aberrations
  • Chromosome banding
  • Chromosomes
  • Cytogenetic analysis
  • Karyotyping
  • Non-Hodgkin lymphoma
  • Small non-cleaved-cell lymphoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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