Chromosome damaging effects of pan masala

R. J. Jaju; R. K. Patel; S. R. Bakshi; A. H. Trivedi; B. J. Dave; S. G. Adhvaryu

doi:10.1016/0304-3835(92)90235-N

Chromosome damaging effects of pan masala

R. J. Jaju, R. K. Patel, S. R. Bakshi, A. H. Trivedi, B. J. Dave, S. G. Adhvaryu

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Effects of aqueous extracts of a popular brand of pan masala with and without tobacco (PM-T and PM) were studied for short duration treatment employing an in vitro system. Metabolic activation with S9 mix was also included. Frequency of all the three cytogenetic endpoints viz., chromosome aberration (CA); sister chromatid exchange (SCE) and % micronucleated cells (% MNC) were found to be elevated significantly in a dose-dependent manner in cultures without metabolic activation. However, addition of S9 activation system resulted in supression of chromosomal damage. Our findings indicate that pan masalas contain water soluble direct acting mutagens.

Original language	English (US)
Pages (from-to)	221-226
Number of pages	6
Journal	Cancer Letters
Volume	65
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(92)90235-N
State	Published - Aug 31 1992
Externally published	Yes

Keywords

aqueous extract
chromosome aberration
micronucleus
pan masala
sister chromatid exchange

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Chromosome damaging effects of pan masala",

abstract = "Effects of aqueous extracts of a popular brand of pan masala with and without tobacco (PM-T and PM) were studied for short duration treatment employing an in vitro system. Metabolic activation with S9 mix was also included. Frequency of all the three cytogenetic endpoints viz., chromosome aberration (CA); sister chromatid exchange (SCE) and % micronucleated cells (% MNC) were found to be elevated significantly in a dose-dependent manner in cultures without metabolic activation. However, addition of S9 activation system resulted in supression of chromosomal damage. Our findings indicate that pan masalas contain water soluble direct acting mutagens.",

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AU - Patel, R. K.

AU - Bakshi, S. R.

AU - Trivedi, A. H.

AU - Dave, B. J.

AU - Adhvaryu, S. G.

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AB - Effects of aqueous extracts of a popular brand of pan masala with and without tobacco (PM-T and PM) were studied for short duration treatment employing an in vitro system. Metabolic activation with S9 mix was also included. Frequency of all the three cytogenetic endpoints viz., chromosome aberration (CA); sister chromatid exchange (SCE) and % micronucleated cells (% MNC) were found to be elevated significantly in a dose-dependent manner in cultures without metabolic activation. However, addition of S9 activation system resulted in supression of chromosomal damage. Our findings indicate that pan masalas contain water soluble direct acting mutagens.

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KW - micronucleus

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KW - sister chromatid exchange

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Chromosome damaging effects of pan masala

Abstract

Keywords

ASJC Scopus subject areas

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