Chromosome deletion of Xq25 in an individual with X-linked lymphoproliferative disease

H. E. Wyandt, H. L. Grierson, W. G. Sanger, J. C. Skare, A. Milunsky, D. T. Purtilo

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

High resolution chromosome analysis was done on lymphoblastoid cell lines, established during the past decade from affected males with X-linked lymphoproliferative disease (XLP) or from obligate female carriers, from 14 families. One cell line, from a male with XLP, has a partial deletion of band Xq25. The constitutional nature of the deletion is confirmed in chromosome studies of peripheral blood from the affected individual and represents the first such structural defect to be described in this disorder. Cell lines from the remaining 13 families do not have cytogenetically detectable deletions. This observation will facilitate precise localization, cloning and sequencing of the gene causing XLP.

Original languageEnglish (US)
Pages (from-to)426-430
Number of pages5
JournalAmerican journal of medical genetics
Volume33
Issue number3
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Wyandt, H. E., Grierson, H. L., Sanger, W. G., Skare, J. C., Milunsky, A., & Purtilo, D. T. (1989). Chromosome deletion of Xq25 in an individual with X-linked lymphoproliferative disease. American journal of medical genetics, 33(3), 426-430. https://doi.org/10.1002/ajmg.1320330331