Chronic administration of nicotine fails to alter the MPTP-induced neurotoxicity in mice

Yiu K. Fung, Lori A. Fiske, Yuen Sum Lau

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

1. 1. The effects of chronic (14 day) administration of nicotine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (15 mg/kg, s.c.)-induced neurotoxicity in C57BL/6 mice were examined. 2. 2. Nicotine pretreatment failed to alter the deficit in locomotor activity and the reduction in striatal levels of dopamine produced by MPTP. 3. 3. Our results do not support a therapeutic action of nicotine in a Parkinsonian animal model.

Original languageEnglish (US)
Pages (from-to)669-672
Number of pages4
JournalGeneral Pharmacology
Volume22
Issue number4
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Pharmacology

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