Chronic Hepatitis B Infection: New Approaches towards Cure

Mojisola Ogunnaike; Srijanee Das; Samiksha S. Raut; Ashrafi Sultana; Mohammad Ullah Nayan; Murali Ganesan; Benson J. Edagwa; Natalia A. Osna; Larisa Y. Poluektova

doi:10.3390/biom13081208

Chronic Hepatitis B Infection: New Approaches towards Cure

Mojisola Ogunnaike, Srijanee Das, Samiksha S. Raut, Ashrafi Sultana, Mohammad Ullah Nayan, Murali Ganesan, Benson J. Edagwa, Natalia A. Osna, Larisa Y. Poluektova

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily therapy can be challenging. This review discusses recent advances in the development of long-acting formulations for HBV treatment and prevention, which could potentially improve adherence. Promising new compounds that target distinct steps of the virus life cycle are summarized. In addition to treatments that suppress viral replication, curative strategies are focused on the elimination of covalently closed circular DNA and the inactivation of the integrated viral DNA from infected hepatocytes. We highlight promising long-acting antivirals and genome editing strategies for the elimination or deactivation of persistent viral DNA products in development.

Original language	English (US)
Article number	1208
Journal	Biomolecules
Volume	13
Issue number	8
DOIs	https://doi.org/10.3390/biom13081208
State	Published - Aug 2023

Keywords

antivirals
chronic hepatitis B
gene editing
hepatitis B virus

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.3390/biom13081208

Cite this

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title = "Chronic Hepatitis B Infection: New Approaches towards Cure",

abstract = "Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily therapy can be challenging. This review discusses recent advances in the development of long-acting formulations for HBV treatment and prevention, which could potentially improve adherence. Promising new compounds that target distinct steps of the virus life cycle are summarized. In addition to treatments that suppress viral replication, curative strategies are focused on the elimination of covalently closed circular DNA and the inactivation of the integrated viral DNA from infected hepatocytes. We highlight promising long-acting antivirals and genome editing strategies for the elimination or deactivation of persistent viral DNA products in development.",

keywords = "antivirals, chronic hepatitis B, gene editing, hepatitis B virus",

author = "Mojisola Ogunnaike and Srijanee Das and Raut, {Samiksha S.} and Ashrafi Sultana and Nayan, {Mohammad Ullah} and Murali Ganesan and Edagwa, {Benson J.} and Osna, {Natalia A.} and Poluektova, {Larisa Y.}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = aug,

doi = "10.3390/biom13081208",

language = "English (US)",

volume = "13",

journal = "Biomolecules",

issn = "2218-273X",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Chronic Hepatitis B Infection

T2 - New Approaches towards Cure

AU - Ogunnaike, Mojisola

AU - Das, Srijanee

AU - Raut, Samiksha S.

AU - Sultana, Ashrafi

AU - Nayan, Mohammad Ullah

AU - Ganesan, Murali

AU - Edagwa, Benson J.

AU - Osna, Natalia A.

AU - Poluektova, Larisa Y.

PY - 2023/8

Y1 - 2023/8

N2 - Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily therapy can be challenging. This review discusses recent advances in the development of long-acting formulations for HBV treatment and prevention, which could potentially improve adherence. Promising new compounds that target distinct steps of the virus life cycle are summarized. In addition to treatments that suppress viral replication, curative strategies are focused on the elimination of covalently closed circular DNA and the inactivation of the integrated viral DNA from infected hepatocytes. We highlight promising long-acting antivirals and genome editing strategies for the elimination or deactivation of persistent viral DNA products in development.

AB - Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily therapy can be challenging. This review discusses recent advances in the development of long-acting formulations for HBV treatment and prevention, which could potentially improve adherence. Promising new compounds that target distinct steps of the virus life cycle are summarized. In addition to treatments that suppress viral replication, curative strategies are focused on the elimination of covalently closed circular DNA and the inactivation of the integrated viral DNA from infected hepatocytes. We highlight promising long-acting antivirals and genome editing strategies for the elimination or deactivation of persistent viral DNA products in development.

KW - antivirals

KW - chronic hepatitis B

KW - gene editing

KW - hepatitis B virus

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U2 - 10.3390/biom13081208

DO - 10.3390/biom13081208

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JO - Biomolecules

JF - Biomolecules

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ER -

Chronic Hepatitis B Infection: New Approaches towards Cure

Abstract

Keywords

ASJC Scopus subject areas

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