Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood

N. Osna, G. Silonova, N. Vilgert, E. Hagina, V. Kuse, V. Giedraitis, A. Zvirbliene, M. Mauricas, A. Sochnev

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production.

Original languageEnglish (US)
Pages (from-to)703-710
Number of pages8
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume57
Issue number8
DOIs
StatePublished - 1997

Keywords

  • Chronic hepatitis C
  • Interferon gamma
  • Interleukin 10
  • Interleukin 12
  • Interleukin 4

ASJC Scopus subject areas

  • Clinical Biochemistry

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