Chronic lymphocytic leukemia of the bladder: An atypical etiology of gross hematuria

Vikas Desai, Sudhir Isharwal, Aydin Pooli, Subodh Lele, Michael Feloney

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Chronic lymphocytic leukemia (CLL) is a rare hematologic disorder with affected patients having complications of frequent infections and possible transformation to a more aggressive malignancy. The occurrence of CLL in the bladder is a rare event, with few reported cases. As a result, its aggressiveness and the optimal course for treatment are unknown. Despite this, its presence in the bladder warrants continued surveillance, as recurrence and progression to other bladder malignancies are possible. We present a 71-year-old woman initially diagnosed with CLL who was plagued by recurrent hematuria and dysuria for over a decade, which lead to multiple negative urologic workups. However, these continued workups eventually lead to her diagnosis of bladder CLL with a subsequent finding of carcinoma in situ that was prompted by a suspicious surveillance cystoscopy performed 4 months after her initial bladder diagnosis. Hence, infiltration of CLL in the urinary bladder merits close follow up, including additional urologic procedures.

Original languageEnglish (US)
Pages (from-to)198-200
Number of pages3
JournalTherapeutic Advances in Urology
Issue number5
StatePublished - Oct 2014


  • bladder cancer
  • carcinoma in situ
  • chronic lymphocytic leukemia
  • gross hematuria
  • recurrent urinary tract infections

ASJC Scopus subject areas

  • Urology


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